(R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid

(R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid - Names and Identifiers

Name	(R)-N-FMOC-4-Bromophenylalanine
Synonyms	Fmoc-D-Phe(4-Br)-OH Fmoc-D-4-Bromophenylalanine Fmoc-4-Bromo-D-phenylalanine 4-Bromo-N-Fmoc-D-phenylalanine (R)-N-FMOC-4-Bromophenylalanine (R)-N-Fmoc-4-Bromophenylalanine (R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid (2R)-3-(4-Bromophenyl)-Fmoc-2-aminopropanoic acid N-(9-FLUORENYLMETHOXYCARBONYL)-4-BROMOPHENYL-D-ALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-BROMO-D-PHENYLALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-4-BROMO-D-PHENYLALANINE (R)-3-(4-BROMO-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID
CAS	198545-76-5
InChI	InChI=1/C24H20BrNO4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28)/t22-/m1/s1

(R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid - Physico-chemical Properties

Molecular Formula	C24H20BrNO4
Molar Mass	466.32
Density	1.4220 (rough estimate)
Melting Point	170-172℃
Boling Point	660.8°C at 760 mmHg
Flash Point	353.4°C
Vapor Presure	2.31E-18mmHg at 25°C
Appearance	White to off-white powder
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.6500 (estimate)
MDL	MFCD00273459

(R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29223990
Hazard Class	IRRITANT

(R)-Fmoc-2-amino-3-(4-bromophenyl)proionoic acid - Introduction

(R)-N-FMOC-4-Bromophenylalanine is a chemical substance that has the following properties:

1. Appearance: usually white to yellowish crystalline powder.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane (DCM).
3. Stability: relatively stable at room temperature, but need to be protected from light.

(R)-N-FMOC-4-Bromophenylalanine are mainly used in solid phase synthesis (SPPS) as one of the building blocks of peptides or proteins. It is commonly used as a protected amino acid to prevent adverse reactions of amino acids during synthesis. In addition, it can also be used for the modification and synthesis of peptides and proteins.

The common method for preparing (R)-N-FMOC-4-Bromophenylalanine is to react D-4-bromophenylalanine with Fmoc-Cl (dimethylaminomethyldiisopropylammonium chloride) under alkaline conditions to generate (R)-N-FMOC-4-Bromophenylalanine.

Regarding the safety information of (R)-N-FMOC-4-Bromophenylalanine, the following matters need to be noted:
1. The substance may be irritating to the eyes, skin and respiratory system. Avoid direct exposure to skin, eyes and mucous membranes when used.
2. During use should wear appropriate protective equipment, such as gloves, goggles and protective mask.
3. The preparation and storage of the substance should be away from fire and heat sources, to avoid flammable and explosive conditions.
4. The use or handling of the substance should be carried out in a well-ventilated area to avoid the risk of inhaling harmful gases.
5. If the substance is accidentally ingested or inhaled, please consult a doctor promptly and provide relevant safety data and material information to the doctor.

Reminder: When using and handling chemicals, Please strictly follow the corresponding safety operation procedures and operate with caution.

Last Update：2024-04-09 20:52:54